Amanda Turkiewicz

Current and Upcoming Research Studies

Current Studies

To learn more about current studies at the Toronto Adult CF Centre, please click on the following links:

Randomized controlled trial of prednisone in cystic fibrosis (CF) pulmonary exacerbations - now recruiting

An Efficacy and Safety Study of SPX-101 Inhalation Solution in Subjects With Cystic Fibrosis (HOPE-1) - now recruiting

EMPIRE CF: A Phase 2 Study to Evaluate the Efficacy, Safety, and Tolerability of CTX-4430 in Adult CF Patients - recrutiment completed, study ongoing

A Study to Evaluate the Safety and Efficacy of Long Term Treatment With VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis Who Have an F508del-CFTR Mutation - ongoing, not open to recruitment

Upcoming Drug Studies

Even when we do not have active studies, the research coordinators are always happy to hear from anyone who is interested in participating in drug studies as there is almost always something in the pipeline! Enrollment for most drug studies is fairly competitive across participating sites and spots tend to fill up quickly. For that reason, we keep a list of people who have expressed interest in a particular study and contact those people as soon as we have any updates on upcoming drug trials. Please let any of the research coordinators know if you would like to be added to this list!

Study coordinators may contact you if you are eligible to participate in this research. If you are interested in knowing more about your eligibility, please contact Leena at rizvil@smh.ca or Katie at griffink@smh.ca

There is an excellent resource to find out what new studies are being done in CF including regular updates with results as studies progress. It is called www.clinicaltrials.gov.

To learn more about upcoming studies at the Toronto Adult CF Centre, please click on the following links:

Study of Safety, Tolerability & Efficacy of PBI 4050 in Cystic Fibrosis Patients With Abnormal Glucose Tolerance - recruiting soon

Recently Completed Clinical Trials

Early Signs of Efficacy Study With Riociguat in Adult Homozygous Delta F508 Cystic Fibrosis Patients

A Study Evaluating the Safety and Efficacy of VX-440 Combination Therapy in Subjects With Cystic Fibrosis

A Phase 1, Single-Center, Open-Label Safety Study of SPX-101 Inhalation Solution in Subjects with Cystic Fibrosis

A Phase 3 Study of VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Who Have One F508del-CFTR Mutation and a Second Mutation That Has Been Demonstrated to be Clinically Responsive to Ivacaftor  

A Phase 3 Study to Evaluate the Efficacy and Safety of Ivacaftor and VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Heterozygous for the F508del-CFTR Mutation 

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor